epitope validator

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epitope validator
Key Features:
  • prediction of B-cell epitopes with unprecedented accuracy
  • customizable combination of different prediction algorithms
  • graphical presentation of calculated antigenicity
  • scoring and ranking of the predicted epitopes depending on the order of the antigenic probability
  • high throughput epitope prediction and analysis
Metalife Epitope Validator is one of the major tools that are developed by the Metalife AG specialists in the predictor package. The Epitope Validator contains several highly efficient antigenic determinant (B-cell epitopes) prediction algorithms. It employs methods and algorithms for predicting the secondary structure, hydropathy, hydrophobicity, flexibility and surface probability, that help to predict real epitopic regions in a given protein sequence.

Several methods are calculating a statistical score for the antigenicity value of each residue in a given sequence. Two of the algorithms are dealing with the calculation of hydrophobicity, hydrophilicity and hydropathy of the sequence based on its primary sequence. The antigenic index method is used to create a linear surface contour profile of the protein.

The graphical user interface is intuitive and close to the most commonly used desktop applications. Its purpose is to facilitate the research in the field of immunology and other related fields, and to support it by achieving more reliable results with less effort.

Metalife Epitope Validator has the functionality to export the results in both ways - to a text document and to a graphical file. It allows the user to send found epitopic regions back to the sequence sets as separate sequences for further analysis.

Combination of the state-of-the-art algorithms for calculating sequence properties in real time is among the main advantages. Its fast and reliable results are easily manageable and compatible with other products. High quality prediction and validation of epitopes reduces the number of false positive epitope sequences. Thus, high accuracy in epitope prediction along with validation of these epitopes using information stored in scientific literature both speeds up and lowers costs of antibody production.

Order installation of local copy of Epitope Validator!

Metalife offers installation of local copy of its products upon licensing. Ordering a local copy benefits private users with the following extra advantages:

  • Data security ensured by the management of all analyses and sources locally in your organization's secured network.
  • Impossibility of competitor companies to track down your searches in public resources and reveal your interests.
  • Custom development of project specific GUI features, new functionalities, DB sources.
  • Completely new decisions implementation upon request.